The 5 Major Functions Of Magnesium Sulfate, Clinical Medication Must See
1. Oral magnesium sulfate solution of different concentrations can have different effects
1. Catalytic effect
Oral administration, because it is not absorbed, forms a certain osmotic pressure in the intestine, so that a large amount of water is retained in the intestine, which stimulates intestinal peristalsis and defecation.
Dissolve 5 to 20 grams of magnesium sulfate in 100 to 400 ml of warm water each time, and take it orally once in the morning. The concentration should not be too high, 5% is better, otherwise defecation will be delayed.
2. Gallbladder effect
Oral administration of high-concentration (33%) magnesium sulfate solution, or direct infusion into the duodenum with a catheter, can stimulate the duodenal mucosa, reflexively cause relaxation of the common bile duct sphincter and contraction of the gallbladder, thereby promoting gallbladder emptying and promoting gallbladder effect. 2-5g each time, 3 times a day, before or between meals. 33% solution can also be taken, 10ml each time.
It should be noted that if a large amount of solution with excessive concentration is taken during catharsis, it can absorb a large amount of water from the tissue and cause dehydration. Therefore, it should be taken on an empty stomach in the morning and drink plenty of water to accelerate the catharsis and prevent dehydration. This product is contraindicated in catharsis for intestinal bleeding, pregnant women, patients with acute abdomen, and menstruating women.
Second, magnesium sulfate injection intravenously can be used as an anticonvulsant.
It is commonly used for gestational hypertension, to lower blood pressure, to treat pre-eclampsia and eclampsia, and to treat preterm labor.
1. Treatment of moderate to severe pregnancy-induced hypertension, preeclampsia and eclampsia. The first dose is 2.5 ~ 4g, diluted with 20ml of 25% glucose injection, slowly intravenously injected within 5 minutes, and maintained by intravenous drip of 1 ~ 2g every hour thereafter. The 24-hour total is 30 g, monitored according to knee tendon reflexes, respiratory rate, and urine output.
2. Treat premature birth. Similar to the dosage and method of treating gestational hypertension, the first loading dose is 4g; after diluting with 20ml of 25% glucose injection, it is slowly injected intravenously within 5 minutes, and then 60ml of 25% magnesium sulfate injection is added to 5% glucose injection Intravenous infusion in 1000ml at a rate of 2g per hour until 2 hours after uterine contractions stopped, and then maintained by oral adrenoreceptor agonists.
3. External use of magnesium sulfate: reduce swelling and inflammation.
Because magnesium sulfate has the pharmacological effects of hypertonicity, swelling and pain relief, it is used in clinical practice and the effect is quite satisfactory.
Use gauze or absorbent cotton to fully soak in 50% magnesium sulfate solution, hot or cold compress can be used, and the symptoms of the affected area need to be determined. If it is phlebitis, it is mostly cold compress. . Generally, depending on the condition of the affected area, apply a wet compress one to several times a day, for 30 minutes at a time.
