Magnesium Sulfate Medical Use

Magnesium Sulfate Medical Use

Medical use Can be used as an anticonvulsant. It is often used for pregnancy-induced hypertension. Lowering blood pressure, treating pre-eclampsia and eclampsia, and also for treating premature birth. Commonly used in the treatment of convulsions, eclampsia, uremia, tetanus and hypertensive...

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Medical use

Can be used as an anticonvulsant. It is often used for pregnancy-induced hypertension. Lowering blood pressure, treating pre-eclampsia and eclampsia, and also for treating premature birth.


Commonly used in the treatment of convulsions, eclampsia, uremia, tetanus and hypertensive encephalopathy. Magnesium sulfate can be used to treat constipation and abnormal fermentation in the intestines.


chemical composition


The main component of this product is magnesium sulfate.


It is a sterile aqueous solution of magnesium sulfate. Magnesium sulfate (MgSO4.7H2O) should be between 95.0% and 105.0% of the indicated amount.


Molecular formula: MgSO4·7H2O


Molecular weight: 246.48


Fold edit this paragraph main effect

(1) Magnesium sulfate can inhibit the central nervous system, relax skeletal muscle, and have the effects of sedation, antispasmodic and reduction of intracranial pressure. Commonly used in the treatment of convulsions, eclampsia, uremia, tetanus and hypertensive encephalopathy. More by 10% magnesium sulfate 10 ml deep intramuscular injection or diluted with 5% glucose into a 2% ~ 2.5% solution slowly instilled. However, it should be noted that direct intravenous injection or high-dose intramuscular injection of magnesium sulfate is very dangerous. Generally, 25% of magnesium sulfate can be used up to 15 ml each time. When using, you should pay attention to the patient's breathing and blood pressure. The slow knee reflex is an important indicator of the sufficient amount of magnesium ion.


(2) Magnesium plays an extremely important role in the metabolism of sugars and proteins. Children in the growth and development period should be supplemented with magnesium if they have indigestion and apply vitamin D.


(3) Magnesium has many physiological functions similar to those of potassium. Because the clinical manifestations of magnesium deficiency are similar to those of potassium deficiency, magnesium deficiency is often overlooked. In the case of potassium deficiency, when potassium is added and the symptoms are still not improved, the possibility of magnesium deficiency should be considered first, so that hypomagnesemia can be corrected in time. Therefore, patients with long-term infusion should pay attention to magnesium supplementation while supplementing potassium. Add 1 gram of magnesium sulfate to the daily infusion to prevent hypomagnesemia.


(4) When patients with cardiac insufficiency use digitalis, they can supplement magnesium salts appropriately to prevent low magnesium and increase the toxicity of digitalis. It is often effective to treat tachycardia with magnesium salts clinically.


(5) Oral magnesium sulfate is rarely absorbed in the intestinal tract and therefore has no such use. However, oral magnesium sulfate has a good cathartic function, so magnesium sulfate is also called Epsom salt. After the oral magnesium sulfate aqueous solution reaches the intestinal lumen, it has a certain osmotic pressure, so that the intestinal water is not absorbed by the intestinal wall. The intestine retains a large amount of water, which can mechanically stimulate the peristalsis of the intestines and defecate. Therefore, magnesium sulfate can be used for the treatment of constipation and abnormal fermentation in the intestine; in combination with an insect repellent, the intestinal worm can be easily discharged. Each time, 5 to 20 g of magnesium sulfate can be dissolved in 100 to 400 ml of warm water and taken orally once a day. The concentration should not be too high, 5% is better, otherwise the bowel movement is delayed.


(6) Magnesium sulfate can stimulate the duodenal mucosa, reflexively causing relaxation of the common bile duct sphincter and contraction of the gallbladder, thereby promoting gallbladder emptying and beneficial bile. It can be used to treat cholecystitis and cholelithiasis, 2 to 5 grams each time, 3 times a day, orally before meals or between meals. 50% magnesium sulfate was diluted to 33% (high concentration), 5 ml Tid.


(7) magnesium sulfate can be used as a gastrointestinal angiography


(8) Anti-inflammatory and swollen 50% of the solution is applied externally to the affected area, which has the effect of reducing inflammation and swelling.


Magnesium sulphate powder can be used for external swelling to treat swelling of the extremities and help to improve rough skin. Magnesium sulfate


Magnesium sulfate is easily soluble in water, and it is not absorbed by oral administration. The magnesium ions and sulfate ions in the aqueous solution are not easily absorbed by the intestinal wall, so that the intestinal osmotic pressure is increased, and the water of the body fluid moves to the intestinal lumen, so that the intestinal volume increases. The intestinal wall expands, thereby stimulating the afferent nerve endings of the intestinal wall, reflexively causing an increase in intestinal peristalsis and catharsis, which acts on all intestinal segments, so the effect is fast and strong. Used as a cathartic and duodenal drainage.


Intravenous and intramuscular injection of magnesium sulfate is mainly used for anticonvulsant. It can cause vasodilation, leading to blood pressure drop. Due to the central inhibition of magnesium sulfate and skeletal muscle relaxation, antihypertensive effect, it is mainly used to relieve eclampsia and tetanus. Waiting for convulsions, but also for the treatment of hypertensive crisis. Also used as a poison to dissolve the salt.


Folding edit this paragraph pharmacological action

1 Intramuscular injection or intravenous injection inhibits and relieves the central nervous system. Magnesium ions inhibit the release of acetylcholine from motor nerve endings, block nerve and muscle conduction, and relax skeletal muscle, so it can effectively prevent and control convulsions (eclampsia);


2 magnesium ions directly act on uterine muscle cells, antagonizing the action of calcium ions on uterine muscle contraction and inhibiting uterine contraction;


3 external 50% solution can be anti-inflammatory and pain relief by hot compress;


4 oral administration is difficult to absorb, so that the osmotic pressure in the intestinal lumen is increased, a large amount of water causes the intestinal tract to expand, and the intestinal wall receptor is stimulated, resulting in diarrhea;


5 oral drug concentration (33%) is beneficial for gallbladder action. Suitable for severe pregnancy-induced hypertension syndrome, threatened premature labor, cervical edema during labor, constipation, etc.


1 Pharmacodynamics Magnesium ions can inhibit the activity of the central nervous system, inhibit the release of acetylcholine from the motor nerve-muscle junction, block the conduction of the neuromuscular junction, reduce or relieve muscle contraction, and have a relaxing effect on vascular smooth muscle. Peripheral vasodilation, lowering blood pressure, thus preventing and treating eclampsia, inhibiting uterine smooth muscle contraction, and can be used to treat premature labor.


2 Pharmacokinetics takes effect 20 minutes after intramuscular injection, and intravenous injection works almost immediately. The effect lasts for 30 minutes, the treatment of pre-eclampsia and eclampsia and the effective blood magnesium concentration is 2 ~ 3.5mmol / L, the effective blood magnesium concentration for the treatment of premature delivery is 2.1 ~ 2.9mmol / L, the individual differences. Both intramuscular and intravenous, the drug is excreted by the kidneys, and the rate of discharge is related to the blood magnesium concentration and glomerular filtration rate.




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